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A review by Alorfi et al
The glucagon component is also what explains retatrutide's most distinctive side effect: dysesthesia (abnormal skin sensations) in 12.520.9% of patients depending on trial, which is not seen with semaglutide or any other approved weight loss medication
Some patients do exceptionally well on semaglutide
Useful tests and checks include: Blood sugar and A1C Kidney function Blood pressure Weight and body composition Any digestive symptoms Report new symptoms promptly rather than waiting for the next visit, and keep a simple journal of side effects, appetite, and energy so your provider can fine-tune your plan
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